Louisiana Senator Bill Cassidy suffered a stunning primary defeat on May 17, 2026, after former President Donald Trump actively campaigned against him. The two-term Republican lost to Trump-endorsed challenger Julia Letlow in a race that became a referendum on loyalty to the former president. Cassidy's 2021 vote to convict Trump during his second impeachment trial proved politically fatal despite his attempts to mend fences with the GOP base. Toronto Star+2
The Louisiana Republican primary featured three candidates, with Cassidy facing particularly fierce opposition from Letlow and another Trump-aligned contender. Trump repeatedly labeled Cassidy as "disloyal" during campaign rallies, while Cassidy attempted to highlight his conservative voting record. Early polling showed Cassidy trailing by double digits in the final weeks before the election. The Independent+1
Cassidy was among seven Republican senators who voted to convict Trump after the January 6 Capitol attack. This group faced coordinated opposition from Trump, who vowed to remove them from office. By 2026, only two of these senators remained in Congress, demonstrating the lasting consequences of crossing Trump within the GOP. The New York Times+1
The Louisiana result signals Trump's continued dominance over Republican primaries six years after leaving office. Political analysts note the outcome may discourage other Republicans from breaking with Trump on key issues. Letlow's victory sets up a November general election where she's favored to keep the seat in Republican hands. Bloomberg+1